Modulation of cardiac beta-adrenergic receptors by dopamine beta-hydroxylase |
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Authors: | P K Ganguly S L Lee G Waghray |
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Institution: | Department of Anatomy, St. Boniface General Hospital Research Centre, Winnipeg, Canada. |
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Abstract: | Incubation of cardiac sarcolemma in the presence of dopamine beta-hydroxylase (DBH), a catecholamine biosynthetic enzyme, increased beta-adrenergic receptor density by 68% as measured by 3H]dihydroalprenolol (DHA) binding. The addition of DBH to plasma membranes isolated from brain, kidney, skeletal muscle, liver and intestine did not alter 3H]DHA binding. Cardiac alpha-receptors were unaffected under similar conditions. Since DBH is coreleased with norepinephrine, these results indicate that a functional coupling of the putative beta-adrenergic receptor with DBH may exist in cardiac muscle. |
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