Antitumor mechanism of Se-containing polysaccharide, a novel organic selenium compound |
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| Authors: | Dejing Shang Qiao Cui Yang Li Zhi Yu Lei Wen Yuan Zhao Jianing Zhang |
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| Affiliation: | (1) Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, 116029, China;(2) College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China |
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| Abstract: | Recent studies on the inhibition of tumor growth by Se-containing polysaccharide were reviewed. Meanwhile, the possible molecular mechanisms of the inhibition of tumor cell growth through antioxidation, induction of tumor cell apoptosis, blockade of cell cycle, and enhancement of immunity by Se-containing polysaccharide were proposed. In the end, the potential application of Se-containing polysaccharide in the prevention and treatment of tumor was elucidated. |
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| Keywords: | Se-containing polysaccharide antitumor anti-oxidant organic selenium apoptosis |
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