关木通水煎剂对大鼠肾脏毒性的实验研究

目的:了解关木通水煎剂对大鼠肾脏毒性作用的毒理学特点。方法:分别给予正常大鼠0．625g·kg-1和10g·kg-1关木通,观察其对肾脏形态和功能的影响。结果:给予0．625g·kg-1。关木通8w k,大鼠肾脏形态和功能无改变。给予10g·kg-1关木通8wk,大鼠小管细胞变性明显,并有肾间质纤维化。结论:长期应用药典剂量关木通不造成明显的肾脏损害,而较大剂量应用则可致明显的肾功能异常。

Aristolochia Manshuriensis Kom. decoction Induces Renal Impairment In Rats

Objective: To investigate mechanism and pathological changes reduced by Aristolochia manshuriensis Kom. decoction in the kidney of rats. Methods: Wistar rats were distributed into three groups. Groupl was normal control, Group 2 was received Aristolochia manshuriensis Kom. decoction 0.625g/kg body weight once daily for 8 weeks. Group 3 was received Aristolochia manshuriensis Kom. decoction 10g/kg body weight once daily for 8 weeks. After administration, mechanism and pathological changes in rats were investigated. Results: There were no abnormal function and pathological changes in the kidneys of rats in Group 2, while the kidneys of rats in Group 3 had obvious tubulointerstitial fibrosis. Conclusion: Taking Aristolochia manshuriensis Kom. in Chinese Pharmacopoeia dose for a long time induced no obvious renal damage, while large dose of Aristolochia manshuriensis Kom. induced significant renal damage.