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Immunomodulation of a prophylactic human papilloma virus vaccine to be effective therapeutically |
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| Authors: | Henry Clinton Maguire Howard I. Maibach |
| Affiliation: | Thomas Jefferson University Hospital, Medical Oncology, Philadelphia, PA 19107, United States |
| Abstract: | A significant subset of head and neck carcinomas are infected with human papilloma virus; prophylactic vaccines can prevent such HPV+ cancers but are ineffective for invasive HPV+ cancers. We intend to make them therapeutic by means of systemic T regulatory cell depletion. |
| Keywords: | Human papilloma virus (HPV) Cyclophosphamide Head and neck cancer T regulatory cell (Treg) Vaccine |
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