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Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects |
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| Authors: | Hyo-Soon Jeong Seung Hoon Lee Hye-Young Yun Kwang Jin Baek Nyoun Soo Kwon Kyoung-Chan Park Dong-Seok Kim |
| Institution: | (1) Department of Biochemistry, Chung-Ang University College of Medicine, 221 Heukseok-dong Dongjak-gu, Seoul, 156-756, Republic of Korea;(2) Department of Dermatology, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Kyoungki-do, 463-707, Republic of Korea |
| Abstract: | BackgroundSphingosylphosphorylcholine (SPC) acts as a potent lipid mediator and signaling molecule in various cell types. In the present study, we investigated the effects of SPC on melanogenesis and SPC-modulated signaling pathways related to melanin synthesis. |
| Keywords: | Akt/LC3 II/Melanocytes/mTOR/sphingosylphosphorylcholine |
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