STK38 at the crossroad between autophagy and apoptosis |
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| Authors: | Carine Joffre Patrice Codogno Manolis Fanto Alexander Hergovich Jacques Camonis |
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| Affiliation: | 1. Cancer Research Center of Toulouse, UMR1037, Toulouse, France;2. INSERM U1151-CNRS UMR 8253, Institut Necker Enfants-Malades, Paris, France;3. Department of Basic and Clinical Neuroscience, Kings College London, London, UK;4. University College London, Cancer Institute, London, UK;5. INSERM U830, Institut Curie, Paris, France |
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| Abstract: | We describe the STK38 protein kinase as a conserved regulator of autophagy. We discovered STK38 as a novel binding partner of Beclin1, a key regulator of autophagy. By combining molecular, cell biological and genetic approaches, we show that STK38 promotes autophagosome formation in human cells and in Drosophila. Furthermore, we also provide evidence demonstrating that STK38 with the small GTPase RalB, assist the co-ordination between autophagic and apoptotic events upon autophagy induction, hence proposing a role for STK38 in determining cellular fate in response to autophagic conditions. |
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| Keywords: | apoptosis autophagy Beclin1 Hippo pathway NDR protein kinase |
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