Biologically active alkylated coumarins from Kayea assamica |
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| Authors: | Lee Kyung-Hee Chai Hee-Byung Tamez Pamela A Pezzuto John M Cordell Geoffrey A Win Khin Khin Tin-Wa Maung |
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| Affiliation: | Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA. |
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| Abstract: | Four coumarin derivatives, theraphins A (1), B (2), C (3), and D (4), along with three known xanthones, 2-hydroxyxanthone, 1,7-dihydroxyxanthone, and 5-hydroxy-1-methoxyxanthone, were isolated from the bark of Kayea assamica (Clusiaceae) native to Myanmar. Their structures were determined using spectroscopic and chemical techniques. The absolute configuration of 1 was established by the modified Mosher ester method. Theraphins A (1), B (2), and C (3) exhibited good cytotoxicity against Col2, KB, and LNCaP human cancer cell lines. Theraphin D (4) showed mild activity only against the KB cell line. The coumarins also exhibited mild antimalarial activities. |
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| Keywords: | Kayea assamica Clusiaceae Alkylated coumarins Xanthones Cytotoxicity Antimalarial activity |
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