Evaluation of Cytokine Production and Phagocytic Activity in Mice Infected with Campylobacter jejuni |
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Authors: | Pedro L Pancorbo Manuel A de Pablo Elena Ortega Aurelia M Gallego Carmen Alvarez Gerardo Alvarez de Cienfuegos |
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Institution: | (1) University of Jaén, Department of Health Sciences, Unit of Microbiology, 23071 Jaén, Spain , ES |
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Abstract: | The effect of several Campylobacter jejuni strains on the immune response was analyzed in mice after intraperitoneal inoculation with 1010 colony forming units (CFU). Three C. jejuni strains were assayed: CCUG 6968 (enterotoxigenic), CCUG 7580 (enterotoxigenic), and CCUG 7440 (non-enterotoxigenic). These
C. jejuni strains induced a peritoneal inflammatory response and an important increase in the peritoneal phagocyte oxidative activity
measured by chemiluminescence assay, as well as an increase in the number of peritoneal cells. Both interleukin-1 (IL-1) and
tumor necrosis factor α (TNFα) production by peritoneal cells were not modified. However, C. jejuni 7440 caused a statistically significant increase in TNFα production. These results have demonstrated that different strains
of C. jejuni induce an increase of the inflammatory response without a significant cytokine release. However, these infectious microorganisms
may be eliminated efficiently by murine macrophages after phagocytosis.
Received: 18 February 1999 / Accepted: 6 May 1999 |
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