Inhibition of tumor cell growth by a human B-cell line |
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| Authors: | Mitsuo Katano Eiro Kubota Fumio Nagumo Tatsuya Matsuo Takeharu Hisatsugu Jutaro Tadano |
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| Affiliation: | (1) Department of Surgery, Saga Medical School, 5-1-1 Nabeshima, 849 Saga, Japan;(2) Department of Oral and Maxillofacial Surgery, Saga Medical School, 5-1-1 Nabeshima, 849 Saga, Japan;(3) Hospital Laboratory, Saga Medical School, 5-1-1 Nabeshima, 849 Saga, Japan |
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| Abstract: | An Adenocarcinoma cell line (Breast-M) and an Epstein-Barr virus (EBV)-infected B-cell line (Hairy-BM) were established from breast tumor tissue. The Hairy-BM was CD20+, CD25 (Tac)+ and surface immunoglobulin (sIg)+. Hairy-BM suppressed the in vitro proliferation of Breast-M in a time and a dose-dependent manner. The suppression was also found in 5 different human tumor targets showing tumor-Hairy-BM binding, but not; in 2 murine tumor targets showing no significant tumor-Hairy-BM binding. Lytic activity of Hairy-BM was found only against Breast-M.Abbreviations sIg Surface immunoglobulin - CTL Cytotoxic T-cells - NK Natural killer - IL2 Interleukin 2 - LAK Lymphokine activated killer - CSN Culture supernatant - MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoolium bromide - PCR Polymerase chain reaction - TIL Tumor-infiltrating lymphocytes - HCL Hairy cell leukemia - TNF Tumor necrosis factor |
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| Keywords: | B-cell line Tumor growth inhibition Breast cancer |
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