Induction of normal ultrastructure by CGRP treatment in dysgenic myotubes |
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| Authors: | L Garcia M Pin?on-Raymond G Romey J P Changeux M Lazdunski F Rieger |
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| Affiliation: | Groupe de Biologie et Pathologie neuromusculaires, U.153 INSERM, Paris, France. |
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| Abstract: | The calcitonin gene-related peptide (CGRP) restores an apparent normal ultrastructure in mdg/mdg muscle cells in vitro, including a normal triadic organization which is known to be essential for excitation-contraction (E-C) coupling. However, neither slow L-type Ca2+ channel activity nor E-C coupling, which are absent in mdg/mdg muscle, were re-established. These observations suggest a potential role of CGRP (and also of cAMP as the intracellular messenger) in the morphological development of the muscle fiber. |
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