Studies on Mefenamic Acid Microparticles: Formulation, In Vitro Release, and In Situ Studies in Rats |
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Authors: | Ferhan Sevgi Aysu Yurdasiper Buket Kaynarsoy Ezgi Turunç Tamer Güneri Ayfer Yalçın |
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Institution: | (1) Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey;(2) Department of Biochemistry, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey |
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Abstract: | In this study, we investigated the in vitro characteristics of mefenamic acid (MA) microparticles as well as their effects on DNA damage. MA-loaded chitosan and alginate
beads were prepared by the ionotropic gelation process. Microsponges containing MA and Eudragit RS 100 were prepared by quasi-emulsion
solvent diffusion method. The microparticles were characterized in terms of particle size, surface morphology, encapsulation
efficiency, and in vitro release profiles. Most of the formulation variables manifested an influence on the physical characteristics of the microparticles
at varying degrees. We also studied the effects of MA, MA-loaded microparticles, and three different polymers on rat brain
cortex DNA damage. Our results showed that DNA damage was higher in MA-loaded Eudragit microsponges than MA-loaded biodegradable
chitosan or alginate microparticles. |
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Keywords: | DNA damage kainic acid mefenamic acid microparticles |
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