幽门螺杆菌感染对冠心病患者血清炎症因子及颈动脉硬化的影响

目的 探讨幽门螺杆菌感染对冠心病患者血清炎症因子及颈动脉硬化的影响。方法 选取2015年6月至2017年2月在安康市中心医院治疗的幽门螺杆菌感染冠心病患者（感染组）50例，以及同时期未被幽门螺杆菌感染的冠心病患者（非感染组）50例。对两组患者血清炎症因子及颈动脉硬化程度进行评估。结果 幽门螺杆菌感染组患者TC、TG及LDL水平均显著高于非感染组，HDL水平显著低于非感染组，差异均有统计学意义（P0.05），感染组患者不稳定斑块的检出率为48.00%，显著高于非感染组的24.00%，差异有统计学意义（P<0.05）。结论 幽门螺杆菌感染能显著升高冠心病患者血脂水平，加重机体炎症反应，并增加患者颈动脉中膜厚度及斑块的不稳定性。

Impact of Helicobacter pylori infection on serum inflammatory factors and carotid arteriosclerosis in patients with coronary heart disease

Objective To explore the impact of Helicobacter pylori (H. pylori ) infection on serum inflammatory factors and carotid atherosclerosis in patients with coronary heart disease. Methods 50 coronary heart disease patients with H. pylori infection (infection group) and 50 ones without (non-infection group) in Ankang central hospital from June 2015 to February 2017 were included. The serum inflammatory factors and severity of carotid atherosclerosis in both groups were evaluated. Results The levels of TC, TG and LDL in infection group were significantly higher, while that of HDL was significantly lower than in non-infection group, respectively (Ps0.05). The detection rate of unstable plaque in infection group (48.00%) was significantly higher than in non-infection group (24.00%) (P<0.05). Conclusion Helicobacter pylori infection can significantly increase the level of blood lipids in patients with coronary heart disease, aggravate the body inflammatory response, and increase the carotid artery intima-media thickness and plaque instability.