金双歧预防早期新生儿高胆红素血症的 临床观察

目的评估益生菌在足月新生儿高胆红素血症中的预防作用及患儿不良反应的发生情况。方法选取成都市妇女儿童中心医院2017年1月至2017年6月产科出生的健康足月儿320例,随机分为预防组(160例)和对照组(160例)。预防组给予益生菌(金双歧)治疗,0.5 g/次,2次/d,连续口服5 d,对照组不做处理。全部新生儿均为母乳喂养,并在生后5 d内检测经皮胆红素平均值,记录临床结果。比较新生儿每天经皮胆红素平均值,需要光疗的比例,不良反应发生情况等一系列临床指标。结果第4、5天预防组新生儿经皮胆红素平均值明显低于对照组,差异有统计学意义(P0.05)。预防组与对照组相比,光疗比例明显降低,差异有统计学意义(P0.05)。两组新生儿发生腹泻和呕吐的情况差异无统计学意义。结论益生菌可以显著降低健康足月新生儿经皮胆红素值,降低需要光疗的比例,安全性较高。

Role of Golden Bifid in prevention of neonatal hyperbilirubinemia

Abstract: Objective To evaluate the effects of probiotics in prevention of neonatal hyperbilirubinemia in full-term newborns. Methods 320 healthy full-term newborns in our hospital from January to June 2017 were divided into control group (n=160) or treatment group (n=160) randomly. The newborns in treatment group were treated with Golden Bifid tablets 0.5 g b.i.d for 5 days, while those in the control group were not given any treatment. All the newborns were breastfed. The average levels of daily percutaneous bilirubin were detected and the clinical outcomes were recorded in five days after birth. Results There was statistically significant difference in the average value of daily percutaneous bilirubin from the fourth day to the fifth day after birth between the two groups (P<0.05). Compared with the control group, the phototherapy ratio in treatment group was significantly lower (P<0.05). There was no statistically significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusion Probiotics can reduce the level of percutaneous bilirubin and the ratio of phototherapy in healthy newborns with high safety.