肠道菌群在中药代谢中的作用

近年来,中药在疾病防治方面所发挥的巨大作用受到了广泛认可。科学合理地解释中药的作用机制将有助于提高其利用价值。越来越多的证据表明肠道菌群在中药治疗中起着至关重要的作用,是打开我国中医药宝库的一把钥匙。肠道菌群在中药代谢过程中发挥着复杂的作用:一方面,人类肠道菌群通过编码多种活性酶,促进了中药组分中的非碳水化合物小分子与碳水化合物在肠道中的代谢过程;另一方面,经肠道菌群代谢转化后产生的中药产物具有多种药理作用。因此,在未来中药研究中应更多地考虑肠道微生态因素,这有助于为中药的药理作用机制研究奠定新的科学基础。

Effect of intestinal microbiota on the metabolic process of traditional Chinese herbal medicine

Abstract: In recent years, the great role of traditional Chinese medicine in the prevention and treatment of diseases has been widely recognized. Scientific and rational explanation of the mechanism of traditional Chinese medicine will contribute to improving its value. There is growing evidence that intestinal microbiota play a vital role in the Chinese medicine treatment and they are the key to open up the treasure house of traditional Chinese medicine. Intestinal microbiota play a complex role in the metabolic process of Chinese medicine ingredients: On the one hand, human intestinal microbiota can promote the metabolic process of noncarbohydrate small molecules and carbohydrates in the intestinal tract by encoding a variety of active enzymes; On the other hand, the metabolites of traditional Chinese medicine, which are transformed by intestinal microbiota, have various pharmacological effects on human body. Therefore, more attention should be paid to the intestinal microecological factors in future researches of traditional Chinese medicine, which will help to lay a new scientific foundation for their pharmacological application.