海藻酸钠寡糖对小鼠免疫及抗氧化功能的影响

目的 研究海藻酸钠寡糖对小鼠免疫及抗氧化活性的影响。方法 采用不同浓度的海藻酸钠寡糖分别对小鼠连续灌胃15 d后，测量小鼠生长性能、小鼠胸腺和脾脏指数以及小鼠血浆中SOD和GSH的活性。结果 海藻酸钠寡糖能促进小鼠的生长性能，提高小鼠的胸腺和脾脏指数。其中给小鼠灌注高浓度的海藻酸钠寡糖15 d后，与对照组相比，小鼠的特定生长率和增重率分别提高了37.0%和48.5%（P<0.01），小鼠胸腺和脾脏指数分别提高了18.8%和21.7%（P<0.01）。海藻酸钠寡糖还能增加小鼠的抗氧化活性，与对照组相比，灌注高浓度海藻酸钠组小鼠的SOD和GSH-Px活性分别提高了92.6%和35.9%（P<0.01）。结论 海藻酸钠寡糖能促进小鼠的生长性能，增强小鼠的免疫和抗氧化功能。

Effects of sodium alginate oligosaccharides on immune and antioxidant function in mice

Abstract: Objective To explore the effects of sodium alginate oligosaccharides (AOS) on immune and antioxidant activities in mice. Methods The mice were fed with different concentrations of AOS for 15 days. The growth performance, thymus and spleen indexes and the activities of SOD and GSH in the plasma of mice were measured. Results After gavaged with high concentration of AOS for 15 days, the specific growth rate and weight gain rate of mice increased by 37.0% and 48.5% (Ps<0.01) respectively, and the thymus and spleen indexes of mice increased by 18.8% and 21.7% (Ps<0.01) respectively. Compared with the control group, the activities of SOD and GSH-Px in the AOS group increased by 92.6% and 35.9% (Ps<0.01) respectively. Conclusion Sodium alginate oligosaccharides can promote the growth performance and enhance the immune function and antioxidant function of mice.