盘基网柄菌发育中的细胞粘附分子及其信号转导

在盘基网柄菌发育早期，DdCAD-1和csA调节了变形虫细胞间的粘着，调控该过程的机制类似于胚胎发育中上皮细胞层的闭合。完成网柄菌发育的一个必需分子是gpl50异嗜性粘附分子。盘基网柄菌β-连环蛋白同源物Aardvark(Aar)的缺乏使细胞间失去粘着连接，Aar也有信号转导功能，调控了前孢子细胞基因的表达。因此，细胞间的粘着是盘基网柄菌发育的一个重要组成部分，并与调控形态发生过程的信号转导有密切相互作用关系。

Adhesion molecules and signal transduction during Dictyostelium development

During early development of Dictyostelium, DdCAD-1 and gp80 regulated cell-cell adhesion betweenDictyostelium cells. The mechanism controlling this process is similar to the epithelial sheet sealing in animals.gp150, a heterophilic cell-surface binding protein, is required for completing multicellular development ofDictyostelium. While the b-catenin homologus Aardvark(Aar) of Dictyostelium is absent, adherent junctionsare lost. Aar also has a function in cell signaling and regulates expression of pre-spore gene. The adhesionmolecules and the cell-cel adhesion are important parts of Dictyostelium development, and may interact with thesignal transduction process relating to morphogenesis of Dictyostelium.