The intracellular Ca2+ channels of membrane traffic |
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Authors: | Kirill K Kiselyov Malini Ahuja Volodymyr Rybalchenko Sandip Patel Shmuel Muallem |
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Institution: | 1.Department of Biological Sciences; University of Pittsburgh; Pittsburgh, PA USA;2.Epithelial Signaling and Transport Section; Molecular Physiology and Therapeutics Branch; National Institute of Dental and Craniofacial Research; National Institutes of Health; Bethesda MD USA;3.Department of Cell and Developmental Biology; University College London; London, United Kingdom |
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Abstract: | Regulation of organellar fusion and fission by Ca2+ has emerged as a central paradigm in intracellular membrane traffic. Originally formulated for Ca2+-driven SNARE-mediated exocytosis in the presynaptic terminals, it was later expanded to explain membrane traffic in other exocytic events within the endo-lysosomal system. The list of processes and conditions that depend on the intracellular membrane traffic includes aging, antigen and lipid processing, growth factor signaling and enzyme secretion. Characterization of the ion channels that regulate intracellular membrane fusion and fission promises novel pharmacological approaches in these processes when their function becomes aberrant. The recent identification of Ca2+ permeability through the intracellular ion channels comprising the mucolipin (TRPMLs) and the two-pore channels (TPCs) families pinpoints the candidates for the Ca2+ channel that drive intracellular membrane traffic. The present review summarizes the recent developments and the current questions relevant to this topic. |
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Keywords: | organelles TRPMLs TPCs calcium membrane traffic fusion fission |
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