Pumilanol,an antiprotozoal isoflavanol from Tephrosia pumila |
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| Institution: | 1. Pharmacognosy and Phytochemistry Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India;2. Department of Chemistry, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram 530 002, Andhra Pradesh, India;3. Centre for Phytochemistry and Pharmacology, Southern Cross University, Lismore, PO Box 157, NSW 2480, Australia;4. Swiss Tropical Institute, Socinstrasse 57, PO Box, CH-4002 Basel, Switzerland |
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| Abstract: | A novel isoflavan-4-ol (pumilanol), (rel)-3β-(2′-hydroxy-4′,5′-methylenedioxyphenyl)-6-methoxy-4α,7-dihydroxybenzo-3,4-dihydropyran (1) and two known flavonoids, tephrinone (2) and rotenone (3) together with lupeol and stigmasterol were isolated from the roots of Tephrosia pumila (Fabaceae) from a collection made in Andhra Pradesh, India. The structures of the compounds were determined by MS, 1D and 2D-NMR spectral analysis. Pumilanol (1) exhibited significant antiprotozoal activity against T. b. rhodensiense, T. cruzi and L. donovani with IC50 of 3.7, 3.35 and 17.2 μg/mL, respectively, but displayed high toxicity towards L-6 (IC50 of 17.12 μg/mL) rat skeletal myoblasts. |
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