The proportion of mutant extracellular mitochondrial DNA increases in lung cancer patients after radiotherapy |
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Authors: | I Yu Strelkova S A Abdullaev G P Snigireva V G Bezlepkin A I Gaziev |
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Institution: | 1.Institute of Theoretical and Experimental Biophysica,Russian Academy of Sciences,Puschino, Moscow Region,Russia;2.Russian Scientific Center of Roentgen-Radiology,Rosmedtechnology, Moscow,Russia |
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Abstract: | Quantitative and qualitative changes in circulating extracellular DNA (ec-DNA) of blood plasma are considered as markers for
diagnosis and prognosis of tumor pathology. We have investigated the content of mutant copies of the circulating mitochondrial
DNA (ec-mtDNA) in blood plasma in 8 patients with lung cancer before and after radiotherapy as well as in healthy young and
elderly donors. It was found that in plasma of healthy elderly donors the proportion of ec-mtDNA with mutations (in the total
circulating DNA) is much higher than in young donors. Before radiotherapy the proportion of ec-mtDNA with mutations was higher
in plasma of lung cancer patients (aged 70–76 years) than that of healthy elderly donors. After radiotherapy of lung cancer
patients a twofold increase in the proportion of ec-mtDNA with mutations was observed in total circulating plasma DNA. This
may be attributed to release of mutant DNA copies from dying tumor cells and also from normal cells injured by the radiation
treatment. |
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