Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors. |
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| Authors: | J S Carter D J Rogier M J Graneto K Seibert C M Koboldt Y Zhang J J Talley |
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| Affiliation: | G.D. Searle-Monsanto, St. Louis, MO 63198, USA. |
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| Abstract: | A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition. |
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