7 -Hydroxylation of taurodeoxycholic acid by a reconstituted system from rat liver microsomes |
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| Authors: | Ingemar Björkhem Henry Danielsson Kjell Wikvall |
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| Affiliation: | Department of Chemistry, Karolinska Institutet, Stockholm, Sweden |
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| Abstract: | A reconstituted system from rat liver consisting of partially purified cytochrome P-450 and cytochrome P-450 reductase was found to catalyze an efficient 7α-hydroxylation of taurodeoxycholic acid in the presence of an NADPH-generating system. Addition of phosphatidyl choline stimulated the reaction slightly. The system had a low capacity to 6β-hydroxylate taurochenodeoxycholic acid and lithocholic acid. |
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