| 芋螺毒素氧化折叠研究进展 |
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| 引用本文： | 吴勇,罗素兰,长孙东亭. 芋螺毒素氧化折叠研究进展[J]. 生物技术通报, 2006, 0(5): 49-53,71 |
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| 作者姓名： | 吴勇 罗素兰 长孙东亭 |
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| 作者单位： | 热带生物资源教育部重点实验室,海南大学生物技术实验中心,海南大学海洋学院,海口,570228 |
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| 基金项目： | 新世纪优秀人才支持计划(NCET-04-0837)，国际科技合作重点项目计划(2005DFA30600)，海南省与海口市重点科技项目资助 |
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| 摘 要： | 芋螺毒素(conotoxin,CTX)是当今生物毒素研究的热点之一,已经成为研究药理学和神经科学的重要工具。因此,芋螺毒素如何在体内和体外进行氧化折叠形成天然构象,获得有生物活性的芋螺毒素,越来越为人们所关注。根据当前研究状况,概述了芋螺毒素氧化折叠的一般过程,并总结了二硫键、PDI(二硫键异构酶)、前体肽等在芋螺毒素氧化折叠中所发挥的作用。此外,还就芋螺毒素氧化重折叠的研究前景和方向进行了展望。
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| 关 键 词： | 芋螺毒素 氧化折叠 二硫键 二硫键异构酶 |
| 收稿时间： | 2006-04-19 |
| 修稿时间： | 2006-04-19 |
Development of Conotoxin Oxidative Folding |
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| Wu Yong,Luo Sulan,ZhangSun Dongting. Development of Conotoxin Oxidative Folding[J]. Biotechnology Bulletin, 2006, 0(5): 49-53,71 |
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| Authors: | Wu Yong Luo Sulan ZhangSun Dongting |
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| Affiliation: | Key Laboratory for Tropical Biological Resources (MOE |
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| Abstract: | Conotoxin is the focus of the biotoxin research.Due to their highly pharmacological potency and target selectivity,they have become useful tools in the researches on pharmacology and neuroscience.Consequently more and more people pay attention to the mechanism of conotoxin oxidative folding and how to form natural conformation in vivo and in vitro.This review focuses on the general process of conopeptide oxidative folding and the factors that facilitate folding of these peptides,such as propeptide,disulfide bond,protein disulfide ismoerase(PDI),low temperature,detergent and modifications of conopeptides etc.The prospects for the oxidative folding of conopeptides are discussed as well in this article. |
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| Keywords: | Conotoxins Oxidative folding Disulfide bonds PDI. |
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