| 钙调蛋白及其结合蛋白对神经递质释放的调控作用 |
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| 引用本文： | 倪炜,王正朝,黄晓红.钙调蛋白及其结合蛋白对神经递质释放的调控作用[J].中国生物化学与分子生物学报,2013,29(4):316-324. |
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| 作者姓名： | 倪炜 王正朝 黄晓红 |
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| 作者单位： | 福建师范大学生命科学学院,福建省发育与神经生物学重点实验室 |
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| 基金项目： | 国家自然科学基金项目项目(No.31040084,No.31101032);福建省自然科学基金项目(No.2008J0004,No.2010J01145,No.2011J01144)~~ |
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| 摘 要： | 钙离子（Ca2+）是调节突触前神经递质的胞吐释放的关键离子信号.作为胞内最普遍存在的钙离子感受器的钙调蛋白（CaM）被发现能通过与多种蛋白的相互作用，调控着突触小泡的生发、运输及再填充，从而传递胞内Ca2+浓度变化的信号，对神经递质的释放及突触电生理活动起到至关重要的调控作用.本文综述了CaM及其结合蛋白是如何参与对突触小泡的胞吐释放和胞吞恢复的调控，并探讨了其中可能的分子机制.
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| 关 键 词： | 钙调蛋白 神经递质 突触小泡 胞吐作用 胞吞作用 |
| 收稿时间： | 2012-12-10 |
Roles of Calmodulin and Calmodulin-binding Proteins in Neurotransmitter Release |
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| NI Wei,WANG Zheng-Chao,HUANG Xiao-Hong.Roles of Calmodulin and Calmodulin-binding Proteins in Neurotransmitter Release[J].Chinese Journal of Biochemistry and Molecular Biology,2013,29(4):316-324. |
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| Authors: | NI Wei WANG Zheng-Chao HUANG Xiao-Hong |
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| Institution: | (Fujian Key Laboratory of Developmental and Neurobiology,College of Life Sciences, Fujian Normal University,Fuzhou 350108,China) |
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| Abstract: | Calcium （Ca2+）is a key ion signal known as the regulator of the presynaptic exocytotic release of neurotransmitters. As a most ubiquitous intracellular calcium sensor, calmodulin（CaM）, together with multiple binding proteins,transmits the variation of intracellular calcium and regulate the steps of various processes of vesicle priming, trafficking and refilling , which determine for the secretion of neurotransmitters. It has been discussed how calmodulin and calmodulin-binding proteins regulate the exocytosis and endocytosis of presynaptic vesicles and the possible mechanisms involved in this review. |
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| Keywords: | calmodulin neurotransmitter synaptic vesicles exocytosis endocytosis |
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