| 大鼠尾壳核衰老变化定量分析：Ⅰ,乙酰胆碱（Ach）系统 |
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| 引用本文： | 高怡 施联蓉. 大鼠尾壳核衰老变化定量分析：Ⅰ,乙酰胆碱（Ach）系统[J]. 动物学报, 1990, 36(1): 58-62 |
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| 作者姓名： | 高怡 施联蓉 |
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| 作者单位： | 北京医科大学细胞生物学教研室 北京(高怡，施联蓉)，北京医科大学细胞生物学教研室 北京(张一) |
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| 摘 要： | 应用二异丙基氟磷酸(DFP)控制的乙酰胆碱酯酶(AChE)药物组化染色显示大鼠尾壳核AChE。图像分析系统测定结果表明:老年大鼠(26—27月龄)尾壳核内胆碱能神经元面积、数目及AChE合成速率均较成年大鼠(3—4月龄)减小。这些现象可能是衰老大鼠尾壳核胆碱能神经元功能障碍的生物学基础。
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| 关 键 词： | 大鼠 AchE 尾壳核 衰老 |
QUANTITATIVE ANALYSIS OF THE AGING CHANGES IN CAUDATO.PUTAMEN NUCLEUS OF RATS I. ACh SYSTEM |
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| GAO YI SHI LIANRONG ZHANG YI. QUANTITATIVE ANALYSIS OF THE AGING CHANGES IN CAUDATO.PUTAMEN NUCLEUS OF RATS I. ACh SYSTEM[J]. Acta Zoologica Sinica, 1990, 36(1): 58-62 |
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| Authors: | GAO YI SHI LIANRONG ZHANG YI |
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| Abstract: | AChE of Caudatoputamen nucleus of rats was demonstrated with the pharmacohistochem-ical regimen method for AChE using DFP. The result of measurement wtih Image Analysis System indicates that there were decreases in the section area, number and rate of AChE synthesis of ACh neurons in the caudatoputamen nucleus of old rast. This would be the biological base of the function disturbance of ACh neurons in the caudatoputamen nucleus of old rats. |
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| Keywords: | Diisopropyl fluorophosphate AChE Caudatoputamen nucleus Aging Rat. |
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