Enols as potent antibacterial agents. |
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| Authors: | A Thorarensen G E Zurenko M T Sweeney K R Marotti T P Boyle |
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| Affiliation: | Department of Medicinal Chemistry, Pharmacia, 7254-209-615, Kalamazoo, MI 49007-4940, USA. atli.thorarensen@pharmacia.com |
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| Abstract: | This paper describes the discovery of alpha-trifluoroketoacetamides as potent antibacterial agents against Gram-positive organisms. The initial SAR indicates that the aryl ethyl side chain is essential in maintaining antibacterial activity. The SAR observations have been utilized to design a bioisostere for the alpha-trifluoroketoacetamide with good activity against Gram-positive organisms. |
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