Rank-based tests for dose finding in nonmonotonic dose-response settings |
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Authors: | Chen Y I |
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Affiliation: | Institute of Statistics, National Central University Chung-Li, Taiwan. ychen@stat.ncu.edu.tw |
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Abstract: | Lim and Wolfe (1997, Biometrics 53, 410-418) proposed rank-based multiple test procedures for identifying the dose levels that are more effective than the zero-dose control in randomized complete block designs when it can be assumed that the efficacy of the increasing dose levels is monotonically increasing up to a point, followed by a monotonic decrease. Modifications of the Lim-Wolfe tests are suggested that provide more practical and powerful alternatives. Two numerical examples are illustrated and the results of a Monte Carlo power study are presented. |
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Keywords: | Dose–response study Lim–Wolfe test Monte Carlo study Randomized block design Step-down closed test Umbrella-pattern treatment effects |
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