A novel B-2 suppressor cell regulating susceptibility/resistance of mice to Toxoplasma gondii infection |
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| Authors: | Mun Hye-Seong Aosai Fumie Fang Hao Piao Lian-Xun Winn Tin Norose Kazumi Yano Akihiko |
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| Institution: | Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan. |
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| Abstract: | Irradiation treatment enhanced resistance of C57BL/6, but not BALB/c against Toxoplasma gondii infection. Six Gy-irradiated (IR) C57BL/6 recipients of B-2 cells from T. gondii-infected C57BL/6 died after infection. B-2 suppressor cells from infected C57BL/6 enhanced production of IL-4 and IL-10 in peritoneal exudate cells (PECs), and down-regulated NO release in peritoneal macrophages after infection. On the other hand, B-2 suppressor cells were not detected in a strain, BALB/c, resistant against infection. These data indicated that irradiation-sensitive B-2 cells regulated susceptibility/resistance in mice against T. gondii infection. |
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| Keywords: | toxoplasma gondii B‐2 suppressor nitric oxide cytokine |
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