| 青藤碱对MsPGN大鼠肾脏病理及ICAM-1表达的影响 |
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| 引用本文： | 方敬,仇新军,闫翠环,陈志强.青藤碱对MsPGN大鼠肾脏病理及ICAM-1表达的影响[J].天然产物研究与开发,2011,23(3):436-439. |
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| 作者姓名： | 方敬 仇新军 闫翠环 陈志强 |
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| 作者单位： | 河北医科大学中西医结合研究所,石家庄,050017 |
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| 基金项目： | 河北省中医药管理局课题 |
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| 摘 要： | 为探讨青藤碱(Sinomenine,SIN)对实验性系膜增生性肾小球肾炎(MsPGN)的病理形态学改善及肾组织中细胞间粘附分子-1(ICAM-1)表达的影响,通过实验建立改良的慢性血清病性MsPGN动物模型,光镜观察肾小球以及肾小管-间质的病理改变情况,采用免疫组织化学法检测ICAM-1的表达并分别进行半定量分析。结果显示:光镜下,模型组与正常组相比,系膜基质指数显著升高(P<0.01),肾小球毛细血管直径明显缩小(P<0.01);青藤碱组与模型组相比,上述病理改变明显减轻,系膜基质指数显著下降(P<0.01),肾小球毛细血管直径明显改善(P<0.01)。肾组织中ICAM-1免疫组化结果显示青藤碱可明显下调ICAM-1的表达,肾组织ICAM-1的相对含量、积分光密度,均显著下降(P<0.01),青藤碱组与雷公藤多苷组相比,二者无统计学意义(P>0.05)。实验表明青藤碱能够有效减轻肾脏病理损害,抑制MsPGN大鼠肾组织ICAM-1的表达,延缓疾病进展。
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| 关 键 词： | 青藤碱 系膜增生性肾小球肾炎 细胞间粘附分子-1 |
Affection of Sinomenine on the Kidney Pathology and Expression of ICAM-1 in the Rats with Mesangial Proliferative Glomerulonephritis |
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| FANG Jing,QIU Xin-jun,YAN Cui-huan,CHEN Zhi-qiang.Affection of Sinomenine on the Kidney Pathology and Expression of ICAM-1 in the Rats with Mesangial Proliferative Glomerulonephritis[J].Natural Product Research and Development,2011,23(3):436-439. |
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| Authors: | FANG Jing QIU Xin-jun YAN Cui-huan CHEN Zhi-qiang |
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| Institution: | FANG Jing,QIU Xin-jun,YAN Cui-huan,CHEN Zhi-qiang Institution of Integrated Traditional Chinese and Western Medicine,Hebei Medical University,Shijiazhuang 050017,China |
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| Abstract: | To explore affection of Sinomenine(SIN) on the kidney pathology and Intercellular cell adhesion molecule-1(ICAM-1) expression in rats with mesangial proliferative glomerulonephritis(MsPGN).The test uses the improvement chronic serum sickness nature MsPGN model,with the light mirror observing mesangial region and kidney tubules-mesenchyma,using immunohistochemical method observe the expression of ICAM-1,at the same time,carries on the semi-definite quantity analysis with the pathology image analysis system.T... |
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| Keywords: | sinomenine mesangial proliferative glomerulonephritis(MsPGN) Intercellular cell adhesion molecule-1(ICAM-1) |
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