Alignment maps and homology analysis of the J-C intron in human, mouse, and rabbit immunoglobulin kappa gene |
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Authors: | Karlin S; Ghandour G |
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Institution: | Department of Mathematics, Stanford University. |
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Abstract: | The statistically significant shared oligonucleotides (block identities) of
the intervening region (J5-C) in the human, mouse, and rabbit
immunoglobulin (Ig)-kappa gene were determined. These identities maintain
their order (do not cross) and never connect with any Ig-kappa segment
external to the intron region. The two regions of pronounced similarity are
(1) the vicinity of the established enhancer element (Queen and Baltimore
1983) and (2) a 200-bp region approximately 1 kb upstream that we have
labeled the second enhancer element. Similarity is strong between the human
and mouse sequences in the neighborhood of the first enhancer element and
more pronounced between the human and rabbit sequences in the vicinity of
the second enhancer region. The overall extent of similarity between the
mouse and rabbit sequences is less than that between the human and mouse
sequences and that between the human and rabbit sequences. All close and
large dyad-symmetry pairings were ascertained and their possible relations
to the enhancer elements discussed.
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