Anomalous growth of Staphylococcus epidermidis in the presence of Silastic and glycopeptide antibiotics |
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| Authors: | J.M.T. Hamilton-Miller Saroj Shah C. Smith |
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| Affiliation: | Department of Medical Microbiology, Royal Free Hospital School of Medicine, Pond Street, London NW3 2QG, UK |
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| Abstract: | Abstract In the presence of supra-inhibitory concentrations of the glycopeptide antibiotics vancomycin and teicoplanin, biofilms of Staphylococcus epidermidis on a Silastic surface produce anomalous growwth. This takes the form of macroscopic, cohesive aggregates of cocci bound together with slime. This phenomenon was intermittent, independent of antibiotic concentrations between 20 and 50 μg ml−1, occured more often with teicoplanin, and was found both with slime-negative strains. |
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| Keywords: | Biofilm Staphylococcus epidermidis Glycopeptide antibiotics Catheter |
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