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Enhanced virulence effect of K1 polysaccharide in neonatal rats challenged withE. coli |
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| Authors: | Steven L. Berk Phyllis Neumann David S. Chi J. Kelly Smith |
| Affiliation: | 1. Department of Medicine, East Tennessee State University, Quillen-Dishner College of Medicine, 37614, Johnson City, TN 2. Veterans Administration Medical Center, 37614, Johnson City, TN 3. Department of Internal Medicine, East Tennessee State University, Quillen-Dishner College of Medicine, 37614, Johnson City, TN |
| Abstract: | Purified K1 polysaccharide enhanced the virulence of non-K1Escherichia coli species when given by orogastric feeding to neonatal rats. Neonatal rats developedE. coli bacteremia when K1 polysaccharide was given concomitantly with non-K1E. coli, whereasE. coli bacteremia did not develop when non-K1E. coli was given alone.E. coli K1 species did cause bacteremia and meningitis when fed to neonatal rats. The mechanism by which k1 polysaccharide enhances virulence can be studied with this model of bacteremia development in neonatal rats. |
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