Studies on copper toxicity in nickel-resistant strains ofNeurospora crassa |
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Authors: | P Maruthi Mohan K Sivarama Sastry |
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Institution: | 1. Department of Biochemistry, Osmania University, 500007, Hyderabad, India
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Abstract: | Copper toxicity has been studied in three nickel-resistant strains ofNeurospora crassa (NiR1, NiR2, and NiR3). NiR1 and NiR2, but not NiR3, were two-to threefold more sensitive than the parent wild strain (N. crassa EM 5297a) to Cu2+ on a normal N medium. On a nitrate N medium, Cu2+ was 16-fold more toxic to NiR3 because of reduced synthesis of nitrite reductase; NiR1 and NiR2 were only fivefold more sensitive to Cu2+, and nitrite reductase synthesis was unaffected. Mn2+ reversed Cu2+ toxicity on normal N medium only, in all strains. Fe3+ counteracted Cu2+ toxicity on nitrate N medium also. It was shown that Cu2+ affected Fe3+ utilization for nitrite reductase synthesis in NiR3 only and that in these Ni2+-resistant strains, Fe3+ antagonized effects of Cu2+, but not of other toxic metal ions. |
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