| 锌离子对急性分离的大鼠骶髓后连合核神经元GABAA受体介导电流的？… |
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| 作者姓名： | Pang ZP Wang DS Xu TL Li JS |
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| 作者单位： | 第四军医大学解剖学教研室,梁銶琚脑研究中心!西安,710032,第四军医大学解剖学教研室,梁銶琚脑研究中心!西安,710032,第四军医大学解剖学教研室,梁銶琚脑研究中心!西安,710032,第四军医大学解剖学教研室,梁銶琚脑研究中心!西安,710032 |
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| 基金项目： | 国家自然科学基金!39770248 |
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| 摘 要： | 采用制霉菌素膜片箝 技术,研究了锌离子对急性分离的大鼠骶髓后连合核神经元ＧＡＢＡＡ受体介导电流的作用。
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| 关 键 词： | Zn^2＋ GABAA受体 骶髓后连合核 电流 神经元 |
Zn2+ depresses GABAA receptor mediated responses in acutely dissociated sacral dorsal commissural neurons |
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| Pang ZP,Wang DS,Xu TL,Li JS.Zn2+ depresses GABAA receptor mediated responses in acutely dissociated sacral dorsal commissural neurons[J].Acta Physiologica Sinica,1998,50(6):649-655. |
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| Authors: | Pang Z P Wang D S Xu T L Li J S |
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| Institution: | Department of Anatomy and K.K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an 710032. |
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| Abstract: | The effects of Zn2 on GABAA-receptor mediated responses in acutely isolated rat sacral dorsal commissural nucleus (SDCN) were studied using nystatin-perforated whole cell rechniques .The results demonstrated that (1) GABA induced inward currents through activation of GABAA~at a holding potential of-40 mV; (2) GABAA-receptor mediated responses were suppressed by Zn2 in a reversible and voltage-independent manner; and (3) in the presence of Zn2 , the concentration-response curve of CABA-induced responses was shifted to the right in a parallel manner. The results suggest that Zn2 allosterically depresses GABAA-receptor mediated currents. |
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| Keywords: | zinc GABA_A-receptor nystatin-perforated whole cell recording dissociated cells sacral dorsal commissura nucleus |
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