|
|||||
|
|
Benzodiazepine inhibitors of the MMPs and TACE. Part 2 |
|
| Authors: | Levin Jeremy I Nelson Frances C Delos Santos Efren Du Mila T MacEwan Gloria Chen James M Ayral-Kaloustian Semiramis Xu Jun Jin Guixian Cummons Terri Barone Dauphine |
| Affiliation: | Wyeth Research, 401N. Middletown Road, Pearl River, NY 10965, USA. levinji@wyeth.com |
| Abstract: | A series of benzodiazepine MMP/TACE inhibitors bearing polar moieties has been synthesized in an effort to optimize inhibitory activity against LPS-stimulated TNF production in human monocytes and oral activity in a murine LPS model. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |