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Increased frequency of specific alleles of the c-Ha-ras gene in Japanese cancer patients |
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| Authors: | Kazuo Honda Kanji Ishizaki Mituo Ikenaga Junya Toguchida Takashi Inamoto Kouichi Tanaka Kazue Ozawa |
| Affiliation: | (1) The Second Department of Surgery, Faculty of Medicine, Kyoto University, Yoshida-konoecho, Sakyo-ku, 606 Kyoto, Japan;(2) Radiation Biology Center, Kyoto University, Yoshida-konoecho, Sakyo-ku, 606 Kyoto, Japan;(3) Department of Orthopedic Surgery, Faculty of Medicine, Kyoto University, Yoshida-konoecho, Sakyo-ku, 606 Kyoto, Japan;(4) Present address: Maizuru Municipal Hospital, Maizuru, 625 Kyoto, Japan |
| Abstract: | Summary We have examined the c-Ha-ras locus in 145 cancer patients of a mixed group and 164 normal individuals in Japan for restriction fragment length polymorphisms and compared the allele distributions in normal and cancer populations. The c-Ha-ras gene is highly polymorphic in Japanese as previously reported in Caucasians. Two rare alleles were found to be present with increased frequencies in Japanese cancer patients. These results suggest that genotype analysis of the c-Ha-ras gene could be used to detect cancer-prone individuals. |
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