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Direct chromatographic resolution of racemic cyclohexylaminoglutethimide and its acetylated metabolite using cellulose-based chiral stationary phase |
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| Authors: | Hassan Y. Aboul-Enein Soliman A. Bakr |
| Abstract: | Racemic cyclohexylaminoglutethimide (±ChAG) and its acetylated metabolite (±ChAG) were resolved by a direct chromatographic method using a Chiracel OD column without derivatization. Maximum resolutions (R) of 4.89 and 0.74 were obtained for the enantiomers of cyclohexylaminoglutethimide and its acetylated metabolite, respectively. |
| Keywords: | chiral chromatography cellulose-based chiral stationary phase aromatase inhibitor cyclohexylaminoglutethimide and metabolite enantiomeric separation |