Adenovirus Internalization and Infection Require Dynamin |
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Authors: | Kena Wang Shuang Huang Archana Kapoor-Munshi and Glen Nemerow |
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Institution: | Department of Immunology, The Scripps Research Institute, La Jolla, California |
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Abstract: | The cell receptors that facilitate adenovirus internalization into cells have been identified; however, the infectious pathway of virus entry has not been established. Adenovirus entry and infection were examined in HeLa cells lacking or overexpressing mutant dynamin, a protein that specifically regulates clathrin-mediated endocytosis. Expression of mutant dynamin significantly reduced adenovirus internalization and gene delivery, indicating a functional requirement for this molecule. These findings are consistent with virus entry via the clathrin-coated pit pathway. |
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