铜绿假单胞菌中鼠李糖脂生物合成的研究进展*

鼠李糖脂因其具有环境友好和卓越的物理化学特性,而有望成为化学合成表面活性剂的替代物。近年来鼠李糖脂得到了广泛的研究,其目的是利用低价的可再生资源进行大规模生产,但目前的研究成果仍不足以选育出更具商业竞争力的鼠李糖脂过量合成菌株。为此,进一步理解鼠李糖脂生物合成的复杂基因调控网络,探索降低生产成本的发酵工艺势在必行。综述了铜绿假单胞菌中鼠李糖脂的生物合成途径、群体感应对主要基因的调控、鼠李糖脂在生物膜形成中所发挥的作用,以及发酵优化对鼠李糖脂产量的影响。有助于加深对鼠李糖脂生物合成的认识,为提高鼠李糖脂产量提供重要参考信息。

Advances in Rhamnolipid Biosynthesis by Pseudomonas aeruginosa Research

Rhamnolipids have emerged as a very promising alternatives to their chemo-synthetic counterparts, due to their environmental compatibility and the remarkable physicochemical properties. In recent years, rhamnolipids have been intensively studied, aiming to large-scale improve the production of rhamnolipids based on low-cost renewable resources. However, the current findings are insufficient to screen over-producing rhamnolipids strains with competitive commercial values. Therefore, it is imperative to in-depth understand the sophisticated gene regulatory network of rhamnolipids biosynthesis and explore the fermentation technology to lower the costs. The biosynthetic pathways and the main gene regulatory factors by quorum sensing involved in rhamnolipids production within Pseudomonas aeruginosa are presented, followed by the role of in biofilm formation, and the effect of fermentation optimization on rhamnolipids yield. It is helpful to enhance our understanding on rhamnolipids biosynthesis and provide important reference information for improving the yield of rhamnolipids.