Clinical usefulness of continuous administration ofNocardia rubra cell wall skeleton (N-CWS) in diffuse panbronchiolitis (DPB) |
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Authors: | Shinichi Ishioka Soichiro Hozawa Kenji Hasegawa Toshifumi Saito Masatoshi Takaishi Michio Yamakido |
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Institution: | (1) Second Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734 Hiroshima, Japan |
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Abstract: | Eight patients with diffuse panbronchiolitis (DPB) who had repeated intractable airway infections were continuously treated withNocardia rubra cell wall skeleton (N-CWS), a biological response modifier. As a result, subjective symptoms were reduced in 6 patients. Antibiotics therapy could be discontinued completely in two patients and the dose of antibiotics could be reduced considerably in two other patients. No adverse reactions in relation to N-CWS were observed. These results suggest that N-CWS is effective in treating erythromycin-resistant DPB.Abbreviations BRM
Biological response modifier
- DPB
Diffuse panbronchiolitis
- EM
erythromycin
- N-CWS
Nocardia rubra cell wall skeleton |
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Keywords: | Nocardia rubra cell wall skeleton diffuse panbronchiolitis erythromycin biological response modifier |
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