Normal excretion of quinolinic acid in Huntington's disease |
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| Authors: | M P Heyes E S Garnett R R Brown |
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| Institution: | 1. Division of Radiology and Nuclear Medicine McMaster University Medical Centre 1200 Main Street West Hamilton, Ontario, Canada L8N 3Z5;2. Department of Human Oncology Wisconsin Clinical Cancer Centre University of Wisconsin Madison, Wisconsin, U.S.A. 53792 |
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| Abstract: | We measured the excretion of the endogenous neurotoxin quinolinic acid in 14 patients with Huntington's disease and in 11 age matched control subjects. Huntingtonian patients excreted less quinolinic acid, than controls. When normalised to urea or creatinine output quinolinic acid excretion was normal. We conclude that Huntington's disease is not associated with a generalised disturbance of quinolinic acid metabolism, however, a local hyperproduction of quinolinic acid cannot be excluded from our results. |
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| Keywords: | To whom correspondence should be addressed |
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