RecX is involved in antioxidant mechanisms of the radioresistant bacterium Deinococcus radiodurans |
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| Authors: | Sheng Duohong Gao Guanjun Tian Bing Xu Zhenjian Zheng Zhiguo Hua Yuejin |
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| Institution: | Institute of Nuclear-Agricultural Sciences, Zhejiang University, 310029 Hangzhou, China. |
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| Abstract: | Deinococcus radiodurans shows remarkable resistance to reactive oxygen species (ROS), generated by irradiation. Disruption of recX (dr1310) in D. radiodurans using targeted mutagenesis method enhanced its ROS scavenging activity, and recX overexpression in this bacterium repressed its antioxidant activity significantly. Further analyses on catalase and superoxide dismutase, two important antioxidant proteins in cells, showed that RecX could repress the induction of antioxidant enzymes, revealing that it negatively regulates the ROS scavenging activity in D. radiodurans. |
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| Keywords: | RecX Deinococcus radiodurans Reactive oxygen species Catalase Superoxide dismutase |
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