Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk |
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Authors: | Jia Li Cheng Lan Raper Jonathan |
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Affiliation: | Department of Neuroscience, University of Pennsylvania School of Medicine, 1115, BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA. |
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Abstract: | Neural crest cells migrate along two discrete pathways within the trunk of developing embryos. In the chick, early migrating crest cells are confined to a ventral pathway medial to the dermamyotome while later cells migrate on a dorsal pathway lateral to the dermamyotome. Here we show that Slits are expressed in the dermamyotome, that early migrating crest cells express the Slit receptors Robo 1 and Robo 2, that Slit2 repels migrating crest cells in an in vitro assay, and that the misexpression of a dominant-negative Robo1 receptor induces a significant fraction of early crest cells to migrate ectopically in the dorso-lateral pathway. These findings suggest that Slits, most likely those expressed in the dermamyotome, help to confine the migration of early crest cells to the ventral pathway. |
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