Gas—liquid chromatographic method for the measurement of plasma levels of d-7,8-dimethoxy-3-methyl-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine acid maleate (SCH-12679) and its major metabolites in aggressive mental retardates |
| |
| Authors: | SF Cooper R Elie JM Albert GB Gravel Y Langlois |
| |
| Institution: | Centre de recherches en sciences de la santé, Institut National de la Recherche Scientifique, 7401, rue Hochelaga, Montréal H1N 3M5, Québec Canada;Service de recherche, Centre Hospitalier Louis-H. Lafontaine, 7401, rue Hochelaga, Montréal H1N 3M5, Québec Canada;Institut de recherches psychiatriques, Centre Hospitalier de Lanaudière, 1000, boulevard Sainte-Anne, Joliette J6E 6J2, Québec Canada;Service de recherche, Centre Hospitalier Louis-H. Lafontaine, 7401, rue Hochelaga, Montréal H1N 3M6, Québec Canada |
| |
| Abstract: | A sensitive gas—liquid chromatographic technique for the quantitative analysis of SCH-12679 (d-7,8-dimethoxy-3-methyl-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine acid maleate) and its major metabolites in plasma of aggressive mental retardates receiving therapeutic doses of the medicament has been developed. The lower limits of detection are 20 ng/ml for SCH-12679, 0.5 ng/ml for 3-desmethyl SCH-12679 and 0.4 ng/ml for 7-desmethyl plus 8-desmethyl SCH-12679. SCH-12679 is estimated with a flame ionization detector. Its metabolites are quantitated using an electron-capture detector after conversion of the compounds to their heptafluorobutyryl derivatives by reaction with the appropriate anhydride. Data on plasma levels of unchanged SCH-12679, 3-desmethyl SCH-12679 and a combination of 7-desmethyl and 8-desmethyl SCH-12679 in fifteen patients treated with the medicament are presented. |
| |
| Keywords: | To whom correspondence should be addressed |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
