Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids |
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| Authors: | Dai Qiyuan Restrepo Blanca I Porcella Stephen F Raffel Sandra J Schwan Tom G Barbour Alan G |
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| Institution: | Department of Microbiology, University of California Irvine, Irvine, CA, USA. |
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| Abstract: | The relapsing fever agent Borrelia hermsii undergoes multiphasic antigenic variation through gene conversion of a unique expression site on a linear plasmid by an archived variable antigen gene. To further characterize this mechanism we assessed the repertoire and organization of archived variable antigen genes by sequencing approximately 85% of plasmids bearing these genes. Most archived genes shared with the expressed gene a
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