Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer |
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Authors: | Dong Lu Xiaodan Yu Yukai Du |
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Institution: | (1) The Chinese Medical Hospital, Qin Zhou, GuangXi Province, People’s Republic of China;(2) Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China;(3) School of Public Health, TongJi Medical College of Huazhong University of Science and Technology, No 13 Hangkong Road, Wuhan, HuBei Province, People’s Republic of China; |
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Abstract: | Many studies have investigated the association between the CYP2E1 5′-flanking region (RsaI/PstI) polymorphism and head and neck cancer susceptibility, but the results were conflicting. In
this meta-analysis, we assessed 24 published studies involving 12,562 subjects of the association between CYP2E1 RsaI/PstI polymorphism and head and neck cancer risk. Using the fixed effects model, we found significant association between
PstI/RsaI polymorphism and head and neck cancer risk OR = 1.11 (95%CI: 1.00–1.22) for c2 allele (P = 0.04) and OR = 1.57 (95% CI: 1.14–2.15) for c2 homozygous (P = 0.006) compared with wild type homozygote]. Significant results were also found in East Asians and Mix populations when
stratified by ethnicity. However, no significant associations were found for Caucasians in all genetic models. Stratified
analyses according to source of controls, significant associations were found only in hospital base controls. In the subgroup
analyses by tumor types, significant association was detected only in oral cancer group, while no significant associations
among laryngeal- or pharyngeal- cancer subgroup. This meta-analysis suggests that the CYP2E1 RsaI/PstI polymorphism may be a risk factor for head and neck cancer in Asians and Mix population, and that different carcinogenic
processes involved in the genesis of various tumor types may exist. |
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