Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2) |
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| Authors: | Anderson David R Hegde Shridhar Reinhard Emily Gomez Leslie Vernier William F Lee Len Liu Shuang Sambandam Aruna Snider Patricia A Masih Liaqat |
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| Affiliation: | Pfizer Global Research and Development, 700 Chesterfield Parkway W, Chesterfield, MO 63017, USA. david.r.anderson@pfizer.com |
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| Abstract: | A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFalpha in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported. |
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