A human moderately repeated Y-specific DNA sequence is evolutionarily conserved in the Y chromosome of the great apes. |
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Authors: | M Guttenbach U Müller M Schmid |
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Affiliation: | Department of Human Genetics, University of Würzburg, Germany. |
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Abstract: | Evolutionary conservation of the human-derived moderately repeated Y-specific DNA sequence Y-190 (DYZ5) was investigated in the chimpanzee, orangutan, and gorilla. Southern blot analysis showed the presence of the sequence in the Y chromosome of all great apes. Pulsed-field gel electrophoresis and in situ hybridization revealed that the repeat is organized in one major block and confined to a small region of the Y chromosome of the three species. DYZ5 was assigned to the proximal short arm of the Y chromosome of the chimpanzee and orangutan and to the long arm of the Y chromosome of the gorilla. In light of its evolutionary conservation, DYZ5 may have an as yet undetermined structural function in the Y chromosome. |
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