Further studies on the structural requirements of agents for immunotherapy of the guinea pig line-10 tumor |
| |
Authors: | E. Ribi R. Toubiana S. M. Strain K. C. Milner C. McLaughlin J. Cantrell I. Azuma B. C. Das R. Parker |
| |
Affiliation: | (1) INSERM — U.95, Unit of Experimental Cancerology and Radiology Plateau de Brabois, F-54500 Vandoeuvre-lès-Nancy, France |
| |
Abstract: | Summary We made a comparative study of the in vivo binding of immunoglobulins (Ig) to a polyoma virus-induced ascitic tumor propagated in syngeneic or allogeneic mice. The Ig coat was found to appear more rapidly and to be denser in H 2-incompatible than in H 2-compatible mice. This suggests that antibodies were fixed specifically on strong normal transplantation antigens (H-2) recognized as non-self by allogeneic mice. Experiments with mice in which immunosuppression had been achieved by means of X-irradiation confirmed that the Ig fixed on SEWA cells are actively bound antibodies. The only mice that could fix Ig on tumor cells were those that had been specifically immunized against cell surface antigens shared by SEWA cells before irradiation, while mice hyperimmunized against nonrelated antigens could not.In partial fulfilment of doctorate thesis requirements |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |