Failure of Corynebacterium parvum to inhibit antipyrine metabolism in man |
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| Authors: | Cindy W Hamilton R L DeAngelis S A Gall B Fisher J K Whisnant |
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| Institution: | (1) Present address: Medical Division, Burroughs Wellcome Co., 3030 Cornwallis Road, 27709 Research Triangle Park, NC, USA;(2) Duke University Medical Center, Durham, North Carolina;(3) University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA |
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| Abstract: | Summary In animals, Corynebacterium parvum lowers the rate of drug metabolism and enhances the pharmacologic effect of drugs requiring hepatic microsomal enzyme activity for elimination. A pilot study was conducted to assess this drug interaction in patients given clinical protocol doses of C. parvum. In individual patients, C. parvum did not reduce microsomal drug metabolism as measured by antipyrine half-life. Conversely, antipyrine elimination appeared to be enhanced in 10 of 14 patients. Results from this small heterogenous patient group are not definitive, and further studies are needed to determine the clinical significance of the effects of nonspecific immunotherapy on drug metabolism. |
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