Electrochemical interactions between some beta-lactam antibiotics and aminoglycoside antibiotics |
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| Authors: | G. M. Eckert F. Gutmann H. Keyzer |
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| Affiliation: | (1) Clinical Pharmacology, The Sydney Hospital, Macquarie Street, 2000 Sydney, NSW, Australia;(2) Department of Chemistry, Texas A&M University, 77843 College Station, TX, USA;(3) Department of Chemistry and Biochemistry, California State University, 90032 Los Angeles, CA, USA |
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| Abstract: | Complexation reactions between the two aminoglycosides tobramycin and gentamycin and the two beta-lactam antibiotics carbenicillin and ticarcillin were studied conductimetrically, in aqueous solution. Carbenicillin and gentamycin form a 2 1 adduct in which about 75% of the antibiotics are bound. Likewise, carbenicillin and tobramycin form a 21 adduct binding about 67% of its components. Tobramycin and ticarcillin also interact, but weakly, binding about 12% of the adduct components. Only a trace of adduct formation was observed between cephalothin and gentamycin and between cephalothin and tobramycin. Cephalothin did not interact with carbenicillin. It appears that the adsorption behavior of the aminoglycosides differs considerably from that of the beta-lactams. |
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